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Henceforth, the FDA's new CGMPs will ensure that supplements are produced in a quality manner, do not contain contaminants or impurities, and are accurately labeled. The rule is effective as of August 24, 2007, for large businesses and somewhat later for small businesses. Watchdog groups immediately pointed out that supplement manufacturers have never been required to prove their products are safe and effective, and the new regulations also fail to require this fundamental evidence of quality. An expert quoted by ABC News stated, "Knowing you have pure and well-made useless crap is a little better than having impure useless crap, but not by much." If you have erectile dysfunction, Peyronie’s disease, or other diagnosed disorders, you may need medical treatment.